Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tilki, D; Nguyen, HG; Dall'Era, MA; Bertini, R; Carballido, JA; Chromecki, T; Ciancio, G; Daneshmand, S; Gontero, P; Gonzalez, J; Haferkamp, A; Hohenfellner, M; Huang, WC; Koppie, TM; Lorentz, CA; Mandel, P; Martinez-Salamanca, JI; Master, VA; Matloob, R; McKiernan, JM; Mlynarczyk, CM; Montorsi, F; Novara, G; Pahernik, S; Palou, J; Pruthi, RS; Ramaswamy, K; Rodriguez Faba, O; Russo, P; Shariat, SF; Spahn, M; Terrone, C; Vergho, D; Wallen, EM; Xylinas, E; Zigeuner, R; Libertino, JA; Evans, CP.
Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus.
Eur Urol. 2014; 66(3):577-583
Doi: 10.1016/j.eururo.2013.06.048
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Zigeuner Richard
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- Abstract:
- Although different prognostic factors for patients with renal cell carcinoma (RCC) and vena cava tumor thrombus (TT) have been studied, the prognostic value of histologic subtype in these patients remains unclear. We analyzed the impact of histologic subtype on cancer-specific survival (CSS). We retrospectively analyzed the records of 1774 patients with RCC and TT who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 US and European centers. Multivariable ordered logistic and Cox regression models were used to quantify the impact of tumor histology on CSS. Overall 5-yr CSS was 53.4% (confidence interval [CI], 50.5-56.2) in the entire group. TT level (according to the Mayo classification of macroscopic venous invasion in RCC) was I in 38.5% of patients, II in 30.6%, III in 17.3%, and IV in 13.5%. Histologic subtypes were clear cell renal cell carcinoma (cRCC) in 89.9% of patients, papillary renal cell carcinoma (pRCC) in 8.5%, and chromophobe RCC in 1.6%. In univariable analysis, pRCC was associated with a significantly worse CSS (p<0.001) compared with cRCC. In multivariable analysis, the presence of pRCC was independently associated with CSS (hazard ratio: 1.62; CI, 1.01-2.61; p<0.05). Higher TT level, positive lymph node status, distant metastasis, and fat invasion were also independently associated with CSS. In our multi-institutional series, we found that patients with pRCC and vena cava TT who underwent radical nephrectomy and tumor thrombectomy had significantly worse cancer-specific outcomes when compared with patients with other histologic subtypes of RCC. We confirmed that higher TT level and fat invasion were independently associated with reduced CSS. Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - pathology
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Renal Cell - pathology
- Carcinoma, Renal Cell - secondary
- Carcinoma, Renal Cell - surgery
- Female -
- Humans -
- Kidney Neoplasms - pathology
- Kidney Neoplasms - surgery
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Invasiveness -
- Nephrectomy -
- Prognosis -
- Retrospective Studies -
- Severity of Illness Index -
- Survival Rate -
- Venae Cavae - pathology
- Venous Thrombosis - pathology
- Venous Thrombosis - surgery
- Young Adult -
- Find related publications in this database (Keywords)
- Renal cell carcinoma
- Histology
- Clear cell
- Papillary