Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Böckle, BC; Jara, D; Nindl, W; Aberer, W; Sepp, NT.
Adrenal insufficiency as a result of long-term misuse of topical corticosteroids.
Dermatology. 2014; 228(4):289-293
Doi: 10.1159/000358427
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- The treatment of chronic inflammatory skin disease is associated with the use of topical corticosteroids. Their efficacy, tolerability and adverse effects depend on several factors, specifically potency, type of preparation, extemporaneous dilutions, quantity used, magnitude of the treated body surface, frequency of application, location, patient age, method of application and condition of the skin barrier. We report on two men suffering from chronic inflammatory skin disease, who presented with fatigue and cushingoid appearance after prolonged self-application of potent corticosteroids. Impairment of the skin barrier due to their underlying skin disease, frequent self-application of topical steroids and repeated application of the entire body led to extensive absorption of these substances, eventually culminating in the suppression of the pituitary-hypothalamic-adrenal axis. In conclusion, topical corticosteroids are effective and well-established therapeutic modalities. However, inappropriate use of topical corticosteroids can cause side effects. © 2014 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Adrenal Insufficiency - chemically induced
- Adult -
- Betamethasone - administration & dosage
- Betamethasone - adverse effects
- Betamethasone - analogs & derivatives
- Chronic Disease -
- Cushing Syndrome - chemically induced
- Dermatitis, Atopic - drug therapy
- Glucocorticoids - administration & dosage
- Glucocorticoids - adverse effects
- Humans -
- Male -
- Psoriasis - drug therapy
- Self Medication - adverse effects
- Time Factors -
- Young Adult -
- Find related publications in this database (Keywords)
- Adrenal insufficiency
- Long-term misuse
- Topical corticosteroids
- Psoriasis vulgaris
- Atopic dermatitis