Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vincent, K; Pichler, M; Lee, GW; Ling, H.
MicroRNAs, genomic instability and cancer.
Int J Mol Sci. 2014; 15(8):14475-14491
Doi: 10.3390/ijms150814475
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- Co-Autor*innen der Med Uni Graz
- Pichler Martin
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- Abstract:
- MicroRNAs (miRNAs) are small non-coding RNA transcripts approximately 20 nucleotides in length that regulate expression of protein-coding genes via complementary binding mechanisms. The last decade has seen an exponential increase of publications on miRNAs, ranging from every aspect of basic cancer biology to diagnostic and therapeutic explorations. In this review, we summarize findings of miRNA involvement in genomic instability, an interesting but largely neglected topic to date. We discuss the potential mechanisms by which miRNAs induce genomic instability, considered to be one of the most important driving forces of cancer initiation and progression, though its precise mechanisms remain elusive. We classify genomic instability mechanisms into defects in cell cycle regulation, DNA damage response, and mitotic separation, and review the findings demonstrating the participation of specific miRNAs in such mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Gene Expression Regulation, Neoplastic - genetics
- Genomic Instability - genetics
- Humans -
- MicroRNAs - genetics
- Neoplasms - genetics
- Find related publications in this database (Keywords)
- microRNAs
- genomic instability
- cancer