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Moscarella, E; Al Jalbout, S; Piana, S; Argenziano, G; Lallas, A; Longo, C; Hofmann-Wellenhof, R; Zalaudek, I.
The stars within the melanocytic garden: unusual variants of Spitz naevi.
Br J Dermatol. 2015; 172(4):1045-1051 Doi: 10.1111/bjd.13347 (- Case Report)
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Hofmann-Wellenhof Rainer; Zalaudek Iris
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Abstract:: Spitz naevi may present a wide spectrum of morphologies. Histopathologically, many variants, including desmoplastic, angiomatoid, verrucous/polypoid, plexiform, pagetoid, halo, myxoid, granulomatous and tubular Spitz naevi have been described. Clinical and dermoscopic features of these unusual variants of Spitz naevi have been reported only rarely. The aim of this study is to describe clinical, dermoscopic and histopathological features of uncommon morphological variants of Spitz naevi in order to raise awareness among clinicians about their peculiar patterns of presentation. We searched our image database retrospectively from 2004 to 2014 for images of excised tumours using Spitz/Reed naevus as a keyword. A total of 307 excised skin lesions with a histopathological diagnosis of Spitz/Reed naevus were found. Among those we identified 13 uncommon variants of Spitz naevi including six cases of desmoplastic Spitz naevus, five cases of angiomatoid Spitz naevus and two cases of verrucous Spitz naevus. These lesions did not fulfil the already described dermoscopic criteria of Spitz naevi, with the exception of angiomatoid Spitz naevi, exhibiting a pinkish background and dotted vessels in dermoscopy. Desmoplastic Spitz naevi may be difficult to differentiate from dermatofibroma clinically, and from melanoma under dermoscopic examination. Verrucous Spitz naevi, despite their relatively unusual clinical features, show reassuring morphological clues histologically, which allows the differential diagnosis from an atypical spitzoid tumour. In all cases an atypical melanocytic lesion could not be excluded under dermoscopy, thus warranting excision and histopathological examination. © 2014 British Association of Dermatologists.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Buttocks -; Dermoscopy -; Extremities -; Female -; Humans -; Male -; Melanoma - pathology; Middle Aged -; Nevus, Epithelioid and Spindle Cell - pathology; Skin Neoplasms - pathology; Torso -