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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kaminska-Winciorek, G; Wydmanski, J; Scope, A; Argenziano, G; Zalaudek, I.
"Neglected nipples": acanthosis nigricans-like plaques caused by avoidance of nipple cleansing.
Dermatol Pract Concept. 2014; 4(3):81-84
Doi: 10.5826/dpc.0403a17
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- Co-authors Med Uni Graz
- Zalaudek Iris
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- Abstract:
- Acanthosis nigricans (AN) develops sporadically or in association with obesity, insulin-resistance and dark pigmentary phenotype. Unusual clinical presentations of AN may be diagnostically vexing. The aim of the report is to present unusual clinical and dermoscopic pictures of hyper-keratotic, brownish lesions of the nipples resembling acanthosis nigricans. Data including clinical and dermoscopic features of two patients with the "neglected nipples": acanthosis nigricans-like (AN-like) hyperpigmented plaques caused by avoidance of nipple cleansing. Beside the anamnestic clue, presentation of AN-like plaques in the "neglected nipples" is limited to the breasts, in the absence of involvement of other flexural sites classically affected by AN. Dermoscopy aids the exclusion of a tumor, as it reveals exclusively structureless, brown-gray-black hyperkeratosis in the absence of criteria associated with melanocytic or non-melanocytic skin neoplasms of the nipple. The "neglected breasts" are easily treated by keratolytic creams and hygiene. The "neglected nipples" condition, presenting as bilateral AN-like papules and plaques of the nipples, is due to avoidance of cleansing of the nipple area, resulting in accumulation of keratotic cellular debris.