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SHR Neuro Cancer Cardio Lipid Metab Microb

Schroeder, S; Pendl, T; Zimmermann, A; Eisenberg, T; Carmona-Gutierrez, D; Ruckenstuhl, C; Mariño, G; Pietrocola, F; Harger, A; Magnes, C; Sinner, F; Pieber, TR; Dengjel, J; Sigrist, SJ; Kroemer, G; Madeo, F.
Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity.
Autophagy. 2014; 10(7):1335-1337 Doi: 10.4161/auto.28919 [OPEN ACCESS]
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Co-authors Med Uni Graz: Harger Alexandra; Pieber Thomas; Sinner Frank Michael
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Abstract:: As the major lysosomal degradation pathway, autophagy represents the guardian of cellular homeostasis, removing damaged and potentially harmful material and replenishing energy reserves in conditions of starvation. Given its vast physiological importance, autophagy is crucially involved in the process of aging and associated pathologies. Although the regulation of autophagy strongly depends on nutrient availability, specific metabolites that modulate autophagic responses are poorly described. Recently, we revealed nucleo-cytosolic acetyl-coenzyme A (AcCoA) as a phylogenetically conserved inhibitor of starvation-induced and age-associated autophagy. AcCoA is the sole acetyl-group donor for protein acetylation, explaining why pharmacological or genetic manipulations that modify the concentrations of nucleo-cytosolic AcCoA directly affect the levels of protein acetylation. The acetylation of histones and cytosolic proteins inversely correlates with the rate of autophagy in yeast and mammalian cells, respectively, despite the fact that the routes of de novo AcCoA synthesis differ across phyla. Thus, we propose nucleo-cytosolic AcCoA to act as a conserved metabolic rheostat, linking the cellular metabolic state to the regulation of autophagy via effects on protein acetylation.
Find related publications in this database (using NLM MeSH Indexing): Acetyl Coenzyme A - metabolism; Animals -; Autophagy -; Cell Nucleus - metabolism; Cytosol - metabolism; Humans -; Longevity -; Metabolic Networks and Pathways -; Mice -; Models, Biological -; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - metabolism
Find related publications in this database (Keywords): autophagy; aging; acetylcoenzyme A; histone acetylation; transcription; epigenetics; ATG