Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gumpert, R; Bodo, K; Spuller, E; Poglitsch, T; Bindl, R; Ignatius, A; Puchwein, P.
Demineralization after balloon kyphoplasty with calcium phosphate cement: a histological evaluation in ten patients.
Eur Spine J. 2014; 23(6):1361-1368
Doi: 10.1007/s00586-014-3239-5
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Gumpert Rainer
- Puchwein Paul
- Co-Autor*innen der Med Uni Graz
- Bodo Koppány Bonifác
- Poglitsch Thomas Franz
- Spuller Ekkehard
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- Abstract:
- Balloon kyphoplasty (BKP) with calcium phosphate cement (CPC) is increasingly being used for spinal surgery in younger patients. In routinely performed follow-up CT scans we observed considerable areas of demineralization in CPC processed vertebrae in several patients. To rule out infections or inflammations histological examinations were planned for these patients. Ten patients (23-54 years; six men) with significant demineralization areas in CT scans after CPC balloon kyphoplasty were selected. Punch biopsies from these areas were taken in local anesthesia using a biopsy needle. One half of the specimen was decalcified and embedded in paraffin, and sections were examined histologically using hematoxylin and eosin, Van Gieson, and trichrome staining. The second half of the specimen was cast directly in methyl methacrylate and sections were examined by Paragon and von Kossa/Safranin staining. Stained slides were viewed under light microscopy. Bone-punch specimens were taken at 17.5 months (mean) after BKP with CPC. In most cases, the cement was well surrounded by newly formed lamellar bone with very tight connections between the cement and new bone. Unmineralized areas were observed sporadically at the cement surface and adjacent to the implant. There were no pronounced signs of inflammation or osteolysis of adjacent bone. No complications were observed during or following patients' biopsy procedures. CPC demonstrated good biocompatibility and osseointegration in clinical use, with no evidence of inflammation or osteonecrosis. Demineralized areas in CT scans could be a result of remodeling of the cancellous bone in vertebral bodies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopsy, Needle -
- Bone Cements -
- Bone Demineralization, Pathologic -
- Calcium Phosphates -
- Humans -
- Kyphoplasty -
- Male -
- Microscopy -
- Middle Aged -
- Osseointegration -
- Osteoblasts - pathology
- Spinal Fractures - surgery
- Spine - pathology
- Tomography, X-Ray Computed -
- Young Adult -
- Find related publications in this database (Keywords)
- Balloon kyphoplasty
- Biocompatibility
- Bone biopsy
- Calcium phosphate cement
- Histology
- Osseointegration
- Vertebra