Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grammer, TB; Kleber, ME; Silbernagel, G; Pilz, S; Scharnagl, H; Tomaschitz, A; König, W; März, W.
Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study).
Atherosclerosis. 2014; 236(2):292-300
Doi: 10.1016/j.atherosclerosis.2014.07.002
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
- Scharnagl Hubert
- Silbernagel Günther
- Tomaschitz Andreas
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- Abstract:
- Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist. Hemoglobin and iron status were determined in 1480 patients with stable angiographic coronary artery disease (CAD) and in 682 individuals in whom CAD had been ruled out by angiography. The multivariate adjusted odds ratios (OR) for CAD in the lowest quartiles of hemoglobin and iron were 1.62 (95%CI: 1.22-2.16), and 2.05 (95%CI: 1.51-2.78), respectively compared to their highest gender-specific quartiles. The fully adjusted ORs for CAD in the lowest quartiles of transferrin saturation, ferritin (F) and soluble transferrin receptor (sTfR)/log10F index were 1.69 (95%CI: 1.25-2.27), 1.98 (95%CI: 1.48-2.65), and 1.64 (95%CI: 1.23-2.18), respectively compared to their highest gender-specific quartiles. When adjusting in addition for iron and ferritin the OR for CAD in the lowest quartiles of hemoglobin was still 1.40 (95%CI: 1.04-1.90) compared to the highest gender-specific quartiles. Thus, the associations between either iron status or low hemoglobin and CAD appeared independent from each other. The sTfR was only marginally associated with angiographic CAD. Both low hemoglobin and iron depletion are independently associated with angiographic CAD. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anemia - epidemiology
- C-Reactive Protein - analysis
- Comorbidity -
- Coronary Angiography -
- Coronary Disease - blood Coronary Disease - epidemiology Coronary Disease - radiography
- Cross-Sectional Studies -
- Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology
- Female -
- Ferritins - blood
- Ferritins - epidemiology
- Hemoglobins - analysis
- Humans -
- Interleukin-6 - blood
- Iron - metabolism
- Male -
- Middle Aged -
- Odds Ratio -
- Prospective Studies -
- Receptors, Transferrin - blood
- Smoking - epidemiology
- Transferrin - analysis
- Find related publications in this database (Keywords)
- Coronary artery disease
- Hemoglobin
- Iron
- Transferrin saturation
- Ferritin
- Soluble transferrin receptor