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Pallapies, D; Peskar, BA; Peskar, BM.
Interaction of 5-aminosalicylic acid with nitric oxide on rat aortic strips and human platelets.
Eur J Pharmacol. 1995; 282(1-3):145-149
Doi: 10.1016%2F0014-2999%2895%2900305-5
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- We have examined the interactions of 5-aminosalicylic acid with nitric oxide (NO). Phenylephrine-precontracted rat aortic strips with intact endothelium were further contracted by 5-aminosalicylic acid (50-200 microM) in a concentration-dependent manner. Removal of endothelium, inhibition of guanylate cyclase by methylene blue, inhibition of NO biosynthesis by NG-nitro-L-arginine as well as in inactivation of NO by oxyhemoglobin abolished the effect of 5-aminosalicylic acid. The antiaggregatory effects of 3-morpholinosydnonimine and rat peritoneal neutrophils, which are due to release of NO, were diminished in a concentration-dependent manner by 5-aminosalicylic acid (50-250 microM). In both experimental models the effects of 5-aminosalicylic acid were significantly reduced by superoxide dismutase in a concentration which alone exhibited no effect. Since NO might act as a cytotoxic and vasodilating mediator, our results suggest that inactivation of NO by 5-aminosalicylic acid could contribute to the therapeutic activity of the drug in inflammatory bowel disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Aminosalicylic Acids - antagonists and inhibitors
- Animals - antagonists and inhibitors
- Anti-Inflammatory Agents, Non-Steroidal - antagonists and inhibitors
- Aorta, Thoracic - metabolism
- Blood Platelets - metabolism
- Humans - metabolism
- Mesalamine - metabolism
- Nitric Oxide - blood
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - pharmacology
- Rats - pharmacology
- Vasoconstriction - drug effects
- Find related publications in this database (Keywords)
- 5-Aminosalicylic Acid
- Nitric Oxide (No)
- Inflammatory Bowel Disease