Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Duettmann, W; Raggam, RB; Huber-Krassnitzer, B; Theiler, G; Seeber, K; Prueller, F; Zollner-Schwetz, I; Prattes, J; Wagner, J; Wölfler, A; Krause, R.
Impact of structured personal on-site patient education on low posaconazole plasma concentrations in patients with haematological malignancies.
Int J Antimicrob Agents. 2014; 44(2):140-144
Doi: 10.1016/j.ijantimicag.2014.03.013
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Düttmann Wiebke
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Krause Robert
- Prattes Jürgen
- Prüller Florian
- Rabensteiner Jasmin
- Raggam Reinhard Bernd
- Theiler Georg
- Wölfler Albert
- Zollner-Schwetz Ines
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- Abstract:
- Low posaconazole plasma concentrations (PPCs) are associated with breakthrough invasive mould infections among patients with haematological malignancies. This study evaluated the influence of structured personal on-site patient education on low PPCs. The study was conducted from July 2012 to May 2013 at the Division of Hematology, Medical University Hospital of Graz (Graz, Austria). PPCs were measured in all patients with haematological malignancies receiving the drug prophylactically. Concentrations above the target of 0.5 mg/L were defined as satisfactory and those below this concentration as low. In patients with low PPCs, structured personal on-site education regarding the intake of posaconazole (e.g. intake with fatty/acid food, prevention of nausea and vomiting) was performed. In total, 258 steady-state PPCs were measured in 65 patients [median PPC 0.59 mg/L, interquartile range 0.25-0.92 mg/L; 141/258 (54.7%) satisfactory]. Diarrhoea was the strongest predictor of low PPCs in the multivariate analysis. Initial steady-state PPCs were sufficient in 29 patients and low in 36 patients. Of the 36 patients with low initial steady-state PPCs, 8 were either discharged or antifungal therapy was modified before a follow-up PPC was obtained; in the remaining 28 patients, personal on-site education was performed. In 12/28 patients (43%) the personal on-site education led to sufficient levels, whilst in 16 (57%) PPCs stayed below the target, although increasing from <0.2 mg/L to >0.3 mg/L in 6 of these patients. In conclusion, personal education appears to be a promising tool to increase low PPCs. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Antifungal Agents - pharmacokinetics
- Antifungal Agents - therapeutic use
- Antifungal Agents -
- Chemoprevention - methods
- Cohort Studies -
- Drug Monitoring -
- Female -
- Hematologic Neoplasms - complications
- Humans -
- Male -
- Medication Adherence -
- Middle Aged -
- Mycoses - prevention & control
- Patient Education as Topic -
- Plasma - chemistry
- Triazoles - pharmacokinetics
- Triazoles - therapeutic use
- Young Adult -
- Find related publications in this database (Keywords)
- Posaconazole
- Therapeutic drug monitoring
- Plasma concentrations
- Haematological malignancy
- Prophylaxis
- Patient education