Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kinzer, M; Hingerl, K; König, J; Reinisch, A; Strunk, D; Huppertz, B; Lang, I.
Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.
Placenta. 2014; 35(7):517-519
Doi: 10.1016/j.placenta.2014.04.004
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Lang-Olip Ingrid
- Co-Autor*innen der Med Uni Graz
- Hingerl Kerstin
- Huppertz Berthold
- König Julia Maria
- Reinisch Andreas
- Strunk Dirk
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- Abstract:
- Cell transplantation is a promising strategy in regenerative medicine for revascularization of ischemic tissues. Based on our observation that placental mesenchymal stromal cells (PMSC) enhance endothelial cell viability in vitro via secretion of angiogenic factors, we asked whether PMSC support vascular growth in vivo. PMSC were isolated from amnion and placental endothelial cells (PLEC) from chorion and either separately or co-transplanted subcutaneously into immune-deficient mice. Co-transplantation resulted in a higher number of perfused human vessels (CD31+/vimentin+) containing mouse glycophorin A+ erythrocytes. Results indicate positive effects of PMSC on neovascularization in vivo, making them attractive candidates to create autologous PMSC/PLEC pairs for research and transplantation. Copyright © 2014 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Endothelial Cells - physiology
- Endothelial Cells - transplantation
- Female -
- Heterografts -
- Humans -
- Mesenchymal Stem Cell Transplantation -
- Mesenchymal Stromal Cells - physiology
- Mice -
- Mice, Inbred NOD -
- Mice, SCID -
- Models, Animal -
- Neovascularization, Physiologic -
- Placenta - blood supply
- Placenta - cytology
- Pregnancy -
- Regenerative Medicine -
- Find related publications in this database (Keywords)
- Human placenta
- Mesenchymal stromal cells
- Vascularization
- Angiogenesis
- Mouse model