Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zabini, D; Heinemann, A; Foris, V; Nagaraj, C; Nierlich, P; Bálint, Z; Kwapiszewska, G; Lang, IM; Klepetko, W; Olschewski, H; Olschewski, A.
Comprehensive analysis of inflammatory markers in chronic thromboembolic pulmonary hypertension patients.
Eur Respir J. 2014; 44(4):951-962
Doi: 10.1183/09031936.00145013
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- Führende Autor*innen der Med Uni Graz
- Olschewski Andrea
- Zabini-Polzer Diana
- Co-Autor*innen der Med Uni Graz
- Balint Zoltan
- Chandran Nagaraj
- Foris Vasile
- Heinemann Akos
- Kwapiszewska-Marsh Grazyna
- Olschewski Horst
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- Abstract:
- Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with chronic inflammation but the pathological mechanisms are largely unknown. Our study aimed to simultaneously profile a broad range of cytokines in the supernatant of pulmonary endarterectomy (PEA) surgical material, as well as prospectively in patients with CTEPH to investigate whether circulating cytokines are associated with haemodynamic and physical characteristics of CTEPH patients. Herein, we show that PEA specimens revealed a significant upregulation of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-γ-induced protein-10 (IP)-10, macrophage inflammatory protein (MIP)1α and RANTES compared to lung tissue from healthy controls. In prospectively collected serum, levels of IL-6, IL-8, IP-10, monokine induced by interferon-γ (MIG) and MIP1α were significantly elevated in CTEPH patients compared to age- and sex-matched healthy controls. In serum of idiopathic pulmonary arterial hypertension (IPAH) patients, only IP-10 and MIG were significantly increased. In CTEPH but not in IPAH, IP-10 was negatively correlated with cardiac index, 6-min walking distance and carbon monoxide diffusion capacity. In vitro, IP-10 significantly increased migration of freshly isolated adventitial fibroblasts. Our study is the first to show that IP-10 secretion is associated with poor pulmonary haemodynamics and physical capacity in CTEPH and might be involved in the pathological mechanism of PEA tissue formation. ©ERS 2014.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
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- Biomarkers - blood
- Chronic Disease -
- Cytokines - blood
- Female -
- Humans -
- Hypertension, Pulmonary - blood Hypertension, Pulmonary - etiology
- Inflammation - blood Inflammation - etiology
- Male -
- Middle Aged -
- Prospective Studies -
- Pulmonary Embolism - blood Pulmonary Embolism - complications