Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fickert, P; Pollheimer, MJ; Beuers, U; Lackner, C; Hirschfield, G; Housset, C; Keitel, V; Schramm, C; Marschall, HU; Karlsen, TH; Melum, E; Kaser, A; Eksteen, B; Strazzabosco, M; Manns, M; Trauner, M; International PSC Study Group (IPSCSG).
Characterization of animal models for primary sclerosing cholangitis (PSC).
J Hepatol. 2014; 60(6):1290-1303
Doi: 10.1016/j.jhep.2014.02.006
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- Führende Autor*innen der Med Uni Graz
- Fickert Peter
- Co-Autor*innen der Med Uni Graz
- Lackner Karoline
- Pollheimer Marion
- Trauner Michael
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- Abstract:
- Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC. Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cholangitis, Sclerosing - pathology Cholangitis, Sclerosing - physiopathology Cholangitis, Sclerosing - therapy
- Disease Models, Animal -
- Humans -
- Find related publications in this database (Keywords)
- Animal model
- Biliary fibrosis
- Bile acids
- Cholangiopathies
- Cholestatic liver disease
- Primary sclerosing cholangitis