Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Emmert-Streib, F; de Matos Simoes, R; Glazko, G; McDade, S; Haibe-Kains, B; Holzinger, A; Dehmer, M; Campbell, F.
Functional and genetic analysis of the colon cancer network.
BMC Bioinformatics. 2014; 15 Suppl 6(16):S6-S6
Doi: 10.1186/1471-2105-15-S6-S6
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- Co-Autor*innen der Med Uni Graz
- Holzinger Andreas
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- Abstract:
- Cancer is a complex disease that has proven to be difficult to understand on the single-gene level. For this reason a functional elucidation needs to take interactions among genes on a systems-level into account. In this study, we infer a colon cancer network from a large-scale gene expression data set by using the method BC3Net. We provide a structural and a functional analysis of this network and also connect its molecular interaction structure with the chromosomal locations of the genes enabling the definition of cis- and trans-interactions. Furthermore, we investigate the interaction of genes that can be found in close neighborhoods on the chromosomes to gain insight into regulatory mechanisms. To our knowledge this is the first study analyzing the genome-scale colon cancer network.
- Find related publications in this database (using NLM MeSH Indexing)
- Colonic Neoplasms - genetics
- Colonic Neoplasms - metabolism
- Computational Biology -
- Gene Expression Profiling -
- Gene Regulatory Networks -
- Humans -
- Proteins - genetics
- Proteins - metabolism