Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hubalek, M; Buchner, H; Mörtl, MG; Schlembach, D; Huppertz, B; Firulovic, B; Köhler, W; Hafner, E; Dieplinger, B; Wildt, L; Dieplinger, H.
The vitamin E-binding protein afamin increases in maternal serum during pregnancy.
Clin Chim Acta. 2014; 434(5):41-47
Doi: 10.1016/j.cca.2014.03.036
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
- Mörtl Manfred Georg
- Schlembach Dietmar
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- Abstract:
- Afamin is a liver-derived plasma glycoprotein with vitamin E-binding properties and a putative function in fertility. This study evaluated serum afamin concentrations during and postpartum to uncomplicated pregnancies and investigated a potential association between afamin concentrations and pregnancy outcome. Afamin serum concentrations were measured in women with uncomplicated pregnancies in a retrospective cohort (n=466) at different gestational ages and a prospective observational study (n=76) in the first, second and third trimester. Furthermore, afamin was determined in the first trimester in a cross-sectional pilot study including women with preeclampsia (PE), pregnancy-induced hypertension (PIH) and women without pregnancy complications (n=13 each). Finally, expression of afamin was investigated in human placental tissue by RT-PCR and immunohistochemistry. Afamin concentrations increased linearly almost two-fold during pregnancy in both retrospective and prospective studies in women without pregnancy complications with median afamin serum concentrations of 61.9 mg/l, 79.6 mg/l, and 98.6 mg/l in the first, second, and third trimester, respectively. After delivery, median afamin concentrations decreased to baseline values of 54.6 mg/l. In the pilot study with pregnancy complications, women with PE displayed significantly higher median afamin concentrations than did women with uncomplicated pregnancy (70.0 mg/l vs. 55.4 mg/l, P=0.007). Expression analyses revealed no placental afamin expression at either mRNA or protein level in uncomplicated pregnancy. A linear increase in the maternally expressed glycoprotein afamin during pregnancy may serve as basic reference for subsequent investigations of afamin in pregnancy-related disorders. Copyright © 2014. Published by Elsevier B.V.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Carrier Proteins - blood
- Cross-Sectional Studies -
- Female -
- Gene Expression Regulation - physiology
- Glycoproteins - blood
- Humans -
- Pilot Projects -
- Pre-Eclampsia - blood
- Pre-Eclampsia - metabolism
- Pregnancy -
- Pregnancy Trimesters -
- Retrospective Studies -
- Serum Albumin -
- Serum Albumin, Human -
- Vitamin E - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- Afamin in pregnancy
- maternal expression
- pregnancy complications
- preeclampsia