Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Garcia-Etienne, CA; Tomatis, M; Heil, J; Friedrichs, K; Kreienberg, R; Denk, A; Kiechle, M; Lorenz-Salehi, F; Kimmig, R; Emons, G; Danaei, M; Heyl, V; Heindrichs, U; Rageth, CJ; Janni, W; Marotti, L; del Turco, MR; Ponti, A; eusomaDB Working Group.
Mastectomy trends for early-stage breast cancer: a report from the EUSOMA multi-institutional European database.
Eur J Cancer. 2012; 48(13): 1947-1956.
Doi: 10.1016/j.ejca.2012.03.008
Web of Science
PubMed
FullText
FullText_MUG
- Study Group Mitglieder der Med Uni Graz:
- Sarlos Dimitri
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- Abstract:
- Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US. Copyright © 2012 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - pathology Breast Neoplasms - surgery
- Databases, Factual -
- Databases, Factual -
- Female -
- Humans -
- Lymphatic Metastasis -
- Mastectomy - methods Mastectomy - trends
- Mastectomy, Segmental - trends
- Middle Aged -
- Survival Rate -
- Young Adult -
- Find related publications in this database (Keywords)
- Mastectomy trends
- Mastectomy rates
- Mastectomy
- Mastectomies
- Trends in Europe
- Rates in Europe
- Surgery trends in Europe
- Surgery for breast cancer
- Breast surgery
- Breast surgery in Europe