Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Ofner, M; Tomaschitz, A; Wonisch, M; Litscher, G.
Complementary treatment of obesity and overweight with salacia reticulata and vitamin d.
Int J Vitam Nutr Res. 2013; 83(4):216-223
Doi: 10.1024/0300-9831/a000162
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Ofner Michael
- Co-Autor*innen der Med Uni Graz
- Litscher Gerhard
- Tomaschitz Andreas
- Wonisch Manfred
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- Abstract:
- The Indian plant root Salacia reticulata, which is rich in alpha-glucosidase inhibitors, is used for metabolic disorders in Ayurvedic medicine. Vitamin D₃ is also used in the treatment of some metabolic diseases. Our goal was to determine its potential effect for humans with obesity. In a randomized open-label study, we investigated 40 healthy participants aged 30 - 60 years, physically active, with a body mass index (BMI) of 25 - 45. The participants were randomly allocated into two groups. Body weight, BMI, and body composition were measured. Both groups (A and B) received a guideline for lifestyle and fitness training for 4 weeks. Group B additionally took one capsule containing 200 mg of Salacia reticulata and 1.6 µg (i. e. 64 IU) Vitamin D₃ (SRD) 3 times/day with the meals. Significant weight and body-fat reduction within 4 weeks was observed. Group A lost 1.8 kg or 2.1 %, group B lost 5.3 kg or 6.1 % (p = 0.03), therefore BMI reduction was achieved. While Group A lost 1.4 % of body fat, group B reduced it by 4.5 % (p = 0.01). These promising results suggest that the combination of Salacia reticulata and Vitamin D₃ might be highly valuable and potent to treat overweight and obesity, especially in addition to a modifying lifestyle program. Further research is needed in addition to this study to clarify pathways and effect mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Body Composition -
- Body Mass Index -
- Exercise -
- Female -
- Humans -
- Life Style -
- Male -
- Middle Aged -
- Obesity - drug therapy
- Overweight - drug therapy
- Plant Extracts - administration & dosage
- Plant Roots - chemistry
- Salacia - chemistry
- Vitamin D - administration & dosage
- Weight Loss -
- Find related publications in this database (Keywords)
- obesity
- vitamin D
- Salacia reticulata
- overweight
- exadipin
- lifestyle
- training