Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Yu, H; Lau, K; Thon, V; Autran, CA; Jantscher-Krenn, E; Xue, M; Li, Y; Sugiarto, G; Qu, J; Mu, S; Ding, L; Bode, L; Chen, X.
Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.
Angew Chem Int Ed Engl. 2014; 53(26):6687-6691
Doi: 10.1002/anie.201403588
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- Co-Autor*innen der Med Uni Graz
- Jantscher-Krenn Evelyn
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- Abstract:
- Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bifidobacterium - enzymology
- Drug Evaluation, Preclinical -
- Enterocolitis, Necrotizing - drug therapy
- Multienzyme Complexes - metabolism
- Oligosaccharides - chemical synthesis
- Oligosaccharides - chemistry
- Oligosaccharides - therapeutic use
- Protective Agents - chemical synthesis
- Protective Agents - chemistry
- Protective Agents - therapeutic use
- Rats -
- Find related publications in this database (Keywords)
- disialyl glycans
- enzymatic synthesis
- enzymes
- necrotizing enterocolitis
- oligosaccharides