Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pizzichetta, MA; Canzonieri, V; Soyer, PH; Rubegni, P; Talamini, R; Massone, C.
Negative pigment network and shiny white streaks: a dermoscopic-pathological correlation study.
Am J Dermatopathol. 2014; 36(5):433-438
Doi: 10.1097/DAD.0000000000000019
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Massone Cesare
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- Abstract:
- It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by the presence of NPN and/or SWS, including histopathologically confirmed dermatofibroma (2), Spitz nevus (3), compound nevus (6), dysplastic nevus (7), and melanoma (7), were evaluated for the presence of NPN, SWS, and blue-white veil. The histopathologic features such as orthokeratosis, orthokeratosis plus nests of pigmented melanocytes at the junction, hypergranulosis, hypergranulosis plus nests of pigmented melanocytes at the junction, epidermal invagination plus orthokeratosis, fibrosis, lamellar fibrosis, and elongation and bridging of rete ridges were evaluated. We found a disagreement in 80% of skin lesions between NPN and fibrosis (P = 0.02). For SWS, a significant agreement emerged with hypergranulosis (76%; P = 0.01), and the same occurred with fibrosis (80%; P = 0.01). Moreover, blue-white veil also displayed a significant agreement with hypergranulosis (68%; P = 0.04). Our findings confirm the correlation of SWS with fibrosis, whereas a clear-cut histopathologic substrate of NPN could not be established.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Dermoscopy -
- Female -
- Fibrosis - pathology
- Humans -
- Male -
- Middle Aged -
- Skin Diseases - pathology
- Skin Neoplasms - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- negative pigment network
- shiny white streaks
- melanoma
- melanocytic nevi
- Spitz nevus
- dermatofibroma