Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tucunduva, L; Ruggeri, A; Sanz, G; Furst, S; Cornelissen, J; Linkesch, W; Mannone, L; Ribera, JM; Veelken, H; Yakoub-Agha, I; González Valentín, ME; Schots, R; Arcese, W; Montesinos, P; Labopin, M; Gluckman, E; Mohty, M; Rocha, V.
Impact of minimal residual disease on outcomes after umbilical cord blood transplantation for adults with Philadelphia-positive acute lymphoblastic leukaemia: an analysis on behalf of Eurocord, Cord Blood Committee and the Acute Leukaemia working party of the European group for Blood and Marrow Transplantation.
Br J Haematol. 2014; 166(5):749-757
Doi: 10.1111/bjh.12970
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- The status of umbilical cord blood transplantation (UCBT) in adults with Philadelphia-positive acute lymphoblastic leukaemia (Ph+ALL) and the impact of minimal residual disease (MRD) before transplant are not well established. We analysed 98 patients receiving UCBT for Ph+ALL in first (CR1) or second (CR2) complete remission (CR1, n = 79; CR2, n = 19) with MRD available before UCBT (92% analysed by reverse transcription polymerase chain reaction). Median age was 38 years and median follow-up was 36 months; 63% of patients received myeloablative conditioning and 42% received double-unit UCBT. Eighty-three patients were treated with at least one tyrosine kinase inhibitor before UCBT. MRD was negative (-) in 39 and positive (+) in 59 patients. Three-year cumulative incidence of relapse was 34%; 45% in MRD+ and 16% in MRD- patients (P =0·013). Three-year cumulative incidence of non-relapse mortality was 31%; it was increased in patients older than 35 years (P = 0·02). Leukaemia-free survival (LFS) at 3 years was 36%; 27% in MRD+ and 49% in MRD- patients (P = 0·05), and 41% for CR1 and 14% for CR2 (P = 0·008). Multivariate analysis identified only CR1 as being associated with improved LFS. In conclusion, MRD+ before UCBT is associated with increased relapse. Strategies to decrease relapse in UCBT recipients with Ph+ALL and MRD+ are needed. © 2014 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Cord Blood Stem Cell Transplantation - adverse effects
- Cord Blood Stem Cell Transplantation - methods
- Disease-Free Survival -
- Disease-Free Survival -
- Female -
- Humans -
- Male -
- Middle Aged -
- Neoplasm, Residual -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- cord blood transplantation
- adult
- acute lymphoblastic leukaemia
- minimal residual disease