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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Gruber-Wackernagel, A; Byrne, SN; Wolf, P.
Polymorphous light eruption: clinic aspects and pathogenesis.
Dermatol Clin. 2014; 32(3):315-334
Doi: 10.1016/j.det.2014.03.012
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Gruber-Wackernagel Alexandra
- Wolf Peter
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- Abstract:
- Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to a photoantigen have been suggested as key factors in the disease. Molecular and immunologic disturbances associated with disease pathogenesis include a failure of skin infiltration by neutrophils and other regulatory immune cells on UVR exposure linked to a disturbed cytokine microenvironment. Standard management is based on prevention. Copyright © 2014 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Disease Management -
- Humans -
- Immunosuppression - adverse effects
- Photosensitivity Disorders - diagnosis
- Photosensitivity Disorders - epidemiology
- Photosensitivity Disorders - etiology
- Prevalence -
- Skin - pathology
- Skin - radiation effects
- Ultraviolet Rays - adverse effects
- Find related publications in this database (Keywords)
- Polymorphous light eruption
- Polymorphic
- Photoantigen
- Immune suppression
- Cytokines
- Chemotaxis
- Photoprotection
- Skin cancer