Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mian, M; Wasle, I; Gamerith, G; Mondello, P; Melchardt, T; Jäger, T; Linkesch, W; Fiegl, M.
R-CHOP versus R-COMP: are they really equally effective?
Clin Oncol (R Coll Radiol). 2014; 26(10):648-652
Doi: 10.1016/j.clon.2014.05.012
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- The first-line standard treatment for diffuse large B-cell lymphoma (DLBCL) is the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). It is associated with cardiotoxicity, which is why new treatment strategies are needed. Liposomial doxorubicin has been proven to reduce these side-effects, but until now a direct comparison regarding efficacy has not yet been published. We retrospectively assessed 364 consecutive DLBCL patients who underwent either R-CHOP (218; 60%) or R-COMP (doxorubicin replaced by non-pegylated liposomal doxorubicin; 146; 40%) in first line and compared outcome and survival. We provide evidence that both regimens induce a high and comparable number of complete remissions and that both are able to cure patients with DLBCL. Confirmatory data are needed. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Monoclonal, Murine-Derived - therapeutic use
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Cyclophosphamide - therapeutic use
- Doxorubicin - administration & dosage
- Doxorubicin - analogs & derivatives
- Doxorubicin - therapeutic use
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- Humans -
- Lymphoma, Large B-Cell, Diffuse - drug therapy
- Lymphoma, Large B-Cell, Diffuse - mortality
- Lymphoma, Large B-Cell, Diffuse - pathology
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- Find related publications in this database (Keywords)
- Diffuse large B-cell lymphoma
- outcome
- R-CHOP
- R-COMP