Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Buder, K; Lapa, C; Kreissl, MC; Schirbel, A; Herrmann, K; Schnack, A; Bröcker, EB; Goebeler, M; Buck, AK; Becker, JC.
Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging.
BMC Cancer. 2014; 14(3):268-268
Doi: 10.1186/1471-2407-14-268
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- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target for both imaging and treatment. To non-invasively assess SSTR expression in MCC using PET and the radiotracers [68Ga]DOTA-D-Phe1-Tyr3-octreotide (DOTATOC) or -octreotate (DOTATATE) as surrogate for tumor burden. In 24 patients with histologically proven MCC SSTR-PET was performed and compared to results of computed tomography (CT). SSTR-PET detected primary and metastatic MCC lesions. On a patient-based analysis, sensitivity of SSTR-PET was 73% for nodal metastases, 100% for bone, and 67% for soft-tissue metastases, respectively. Notably, brain metastases were initially detected by SSTR-PET in 2 patients, whereas liver and lung metastases were diagnosed exclusively by CT. SSTR-PET showed concordance to CT results in 20 out of 24 patients. Four patients (17%) were up-staged due to SSTR-PET and patient management was changed in 3 patients (13%). SSTR-PET showed high sensitivity for imaging bone, soft tissue and brain metastases, and particularly in combination with CT had a significant impact on clinical stage and patient management.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Brain Neoplasms - diagnostic imaging
- Brain Neoplasms - pathology
- Brain Neoplasms - secondary
- Carcinoma, Merkel Cell - diagnostic imaging
- Carcinoma, Merkel Cell - genetics
- Carcinoma, Merkel Cell - pathology
- Carcinoma, Merkel Cell - therapy
- Female -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Male -
- Middle Aged -
- Molecular Imaging -
- Octreotide - analogs & derivatives
- Positron-Emission Tomography - methods
- Radiopharmaceuticals -
- Receptors, Somatostatin - biosynthesis
- Receptors, Somatostatin - therapeutic use
- Somatostatin - metabolism
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Merkel cell carcinoma
- Molecular imaging
- Somatostatin receptor expression
- Positron emission tomography