Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Longo, C; Lallas, A; Kyrgidis, A; Rabinovitz, H; Moscarella, E; Ciardo, S; Zalaudek, I; Oliviero, M; Losi, A; Gonzalez, S; Guitera, P; Piana, S; Argenziano, G; Pellacani, G.
Classifying distinct basal cell carcinoma subtype by means of dermatoscopy and reflectance confocal microscopy.
J Am Acad Dermatol. 2014; 71(4):716-724
Doi: 10.1016/j.jaad.2014.04.067
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zalaudek Iris
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- Abstract:
- The current guidelines for the management of basal cell carcinoma (BCC) suggest a different therapeutic approach according to histopathologic subtype. Although dermatoscopic and confocal criteria of BCC have been investigated, no specific studies were performed to evaluate the distinct reflectance confocal microscopy (RCM) aspects of BCC subtypes. To define the specific dermatoscopic and confocal criteria for delineating different BCC subtypes. Dermatoscopic and confocal images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Frequencies of dermatoscopic and confocal parameters are provided. Univariate and adjusted odds ratios were calculated. Discriminant analyses were performed to define the independent confocal criteria for distinct BCC subtypes. Eighty-eight BCCs were included. Dermatoscopically, superficial BCCs (n=44) were primarily typified by the presence of fine telangiectasia, multiple erosions, leaf-like structures, and revealed cords connected to the epidermis and epidermal streaming upon RCM. Nodular BCCs (n=22) featured the classic dermatoscopic features and well outlined large basaloid islands upon RCM. Infiltrative BCCs (n=22) featured structureless, shiny red areas, fine telangiectasia, and arborizing vessels on dermatoscopy and dark silhouettes upon RCM. The retrospective design. Dermatoscopy and confocal microscopy can reliably classify different BCC subtypes. Copyright © 2014 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Carcinoma, Basal Cell - classification
- Carcinoma, Basal Cell - pathology
- Carcinoma, Basal Cell - ultrastructure
- Cohort Studies -
- Confidence Intervals -
- Dermoscopy -
- Female -
- Humans -
- Logistic Models -
- Male -
- Microscopy, Confocal -
- Middle Aged -
- Neoplasm Invasiveness - pathology
- Neoplasm Staging -
- Observer Variation -
- Odds Ratio -
- Retrospective Studies -
- Skin Neoplasms - classification
- Skin Neoplasms - pathology
- Skin Neoplasms - ultrastructure
- Find related publications in this database (Keywords)
- basal cell carcinoma
- dermatoscopy
- dermoscopy
- diagnosis
- infiltrative basal cell carcinoma
- nodular basal cell carcinoma
- reflectance confocal microscopy
- superficial basal cell carcinoma