Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aigner, B; Ugurel, S; Kaddu, S; Becker, JC.
[Cutaneous sarcomas: update on selected fibrohistiocytic and myofibroblastic tumors].
Hautarzt. 2014; 65(7):614-622
Doi: 10.1007/s00105-013-2738-3
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Sadoghi Birgit
- Co-authors Med Uni Graz
- Kaddu Steven
- Ugurel-Becker Selma
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- Abstract:
- Malignant fibrohistiocytic tumors are a heterogeneous group of mesenchymal neoplasms that may occur in the skin and subcutaneous tissues. Diagnosis of these tumors may be difficult, as they are rare, and a wide morphological diversity of types and subtypes has been described. In this update, relevant aspects of selected entities like dermatofibrosarcoma protuberans, desmoid tumor, atypical fibroxanthoma, pleomorphic dermal sarcoma, and myxofibrosarcoma are discussed according to the WHO classification of 2013. The typical clinical feature of these tumors is their mostly asymptomatic appearance. For diagnosis, the histologic workup is therefore the key feature; herein immunohistochemistry as well as molecular diagnostics become increasingly important. The primary treatment for locally resectable tumors is complete surgical removal; chemotherapy, radiation, and targeted therapies with kinase inhibitors are available for inoperable and metastatic disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Chemoradiotherapy - methods
- Dermatologic Surgical Procedures - methods
- Humans -
- Molecular Targeted Therapy - methods
- Protein Kinase Inhibitors - therapeutic use
- Sarcoma - diagnosis
- Sarcoma - therapy
- Skin Neoplasms - diagnosis
- Skin Neoplasms - therapy
- Find related publications in this database (Keywords)
- Histology
- Diagnosis
- Dermatofibrosarcoma protuberans
- Desmoid tumor
- Therapy