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Selected Publication:
Fürnsinn, C; Alma, M; Roden, M; Pieber, T; Nowotny, P; Schneider, B; Waldhäusl, W.
Insulin-like growth factor-I inhibits insulin and amylin secretion in conscious rats.
Endocrinology. 1994; 135(5):2144-2149
Doi: 10.1210/en.135.5.2144
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- Co-authors Med Uni Graz
- Pieber Thomas
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- Abstract:
- Human recombinant insulin-like growth factor-I (IGF-I) exerts insulin-like antidiabetic properties in vitro and in vivo. To determine the effects of IGF-I infusion on insulin and amylin release, plasma glucose of freely moving undisturbed rats was constantly maintained at 13.9 mmol/liter by variable glucose infusion for 120 min in three groups of fasted Sprague-Dawley rats (hyperglycemic clamp technique). Group A, vehicle infusion (control group); group B, bolus 0.39 nmol plus 0.39 nmol/h IGF-I continously; and group C, bolus 1.96 nmol plus 1.96 nmol/h IGF-I continuously. During the steady-state phase of the experiment, IGF-I dose dependently reduced plasma insulin (pmol/liter: A, 718 +/- 58; B, 613 +/- 35, NS vs. A; C, 408 +/- 21, P < 0.01 vs. A; dose-response effect: P < 0.0001), plasma amylin (pmol/liter: A, 10.2 +/- 0.6; B, 8.8 +/- 0.5, NS vs. A; C, 5.8 +/- 0.4, P < 0.01 vs. A; dose-response effect: P < 0.0001), and net glucose uptake (mumol/kg.min: A, 188 +/- 12; B, 160 +/- 12, NS vs. A; C, 134 +/- 7, P < 0.01 vs. A; dose-response effect: P < 0.0025). At the same time, the ratio of plasma insulin/plasma amylin (mol/mol: A, 72 +/- 6; B, 71 +/- 5; C, 74 +/- 9; NS), the ratio of net glucose uptake/plasma insulin (mumol/kg.min per pmol/liter: A, 0.28 +/- 0.03; B, 0.27 +/- 0.02; C, 0.36 +/- 0.04; NS), and glycogen content of liver, heart, and various hindlimb muscles remained unaffected. The results demonstrate that IGF-I is a potent inhibitor of insulin and amylin release in healthy rats exposed to hyperglycemia and suggest that IGF-I infusion inhibits hormone secretion from pancreatic beta cells at infusion rates that do not affect insulin-stimulated glucose uptake by peripheral tissues.
- Find related publications in this database (using NLM MeSH Indexing)
- Amyloid - blood
- Animals - blood
- Consciousness - physiology
- Dose-Response Relationship, Drug - physiology
- Glucose - metabolism
- Glycogen - analysis
- Homeostasis - analysis
- Hyperglycemia - blood
- Insulin - blood
- Insulin-Like Growth Factor I - pharmacology
- Liver - chemistry
- Male - chemistry
- Muscle, Skeletal - chemistry
- Radioimmunoassay - chemistry
- Rats - chemistry
- Rats, Sprague-Dawley - chemistry