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Selected Publication:
Desoye, G; Schmon, B; Gmoser, G; Friedl, H; Urdl, W; Weiss, PA.
Insulin binding to erythrocytes of nonpregnant women: a reevaluation, underlining the importance of body weights even in nonobese subjects.
CLIN CHIM ACTA 1992 207: 57-71.
Doi: 10.1016/0009-8981(92)90150-O
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- Leading authors Med Uni Graz
- Desoye Gernot
- Co-authors Med Uni Graz
- Urdl Wolfgang
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- Abstract:
- Insulin binding to erythrocytes was measured in 18 healthy, non-obese women in the follicular phase and in 6 women in the mid-luteal phase of the same menstrual cycle. The presence of 55 nM and 220 nM monoclonal anti-IGF I receptor antibody (alpha-IR3) reduced only the number of low affinity binding sites for insulin by 20% and 33%, respectively. Women with relative body weights 110-119% had a lower number of high affinity receptors and an increased high affinity compared to women with relative body weights 91-109%. In women with relative body weights greater than or equal to 100%, maximum specific binding and high affinity constants increased and the receptor numbers decreased from the follicular to the luteal phase, whereas in women with relative body weights less than 100% the parameter changes were reverted. The data indicate: (1) erythrocytes contain two different classes of binding sites for insulin, (2) IGF I receptors might contribute to low-affinity binding of insulin to erythrocytes and (3) the relative body weight must be considered even for 'non-obese' control groups used in insulin binding studies of various clinical conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Body Weight -
- Erythrocytes - metabolism
- Female - metabolism
- Humans - metabolism
- Insulin - metabolism
- Menstrual Cycle - blood
- Models, Statistical - blood
- Receptor, Insulin - metabolism