Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pascale, P; Shah, AJ; Roten, L; Scherr, D; Komatsu, Y; Ramoul, K; Daly, M; Denis, A; Derval, N; Sacher, F; Hocini, M; Jaïs, P; Haïssaguerre, M.
Pulmonary veins to left atrium cycle length gradient predicts procedural and clinical outcomes of persistent atrial fibrillation ablation.
Circ Arrhythm Electrophysiol. 2014; 7(3):473-482
Doi: 10.1161/CIRCEP.113.001264
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- Co-Autor*innen der Med Uni Graz
- Scherr Daniel
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- Abstract:
- Rapid pulmonary vein (PV) activity has been shown to maintain paroxysmal atrial fibrillation (AF). We evaluated in persistent AF the cycle length (CL) gradient between PVs and the left atrium (LA) in an attempt to identify the subset of patients where PVs play an important role. Ninety-seven consecutive patients undergoing first ablation for persistent AF were studied. For each PV, the CL of the fastest activation was assessed over 1 minute (PVfast) using Lasso recordings. The PV to LA CL gradient was quantified by the ratio of PVfast to LA appendage (LAA) AF CL. Stepwise ablation terminated AF in 73 patients (75%). In the AF termination group, the PVfast CL was much shorter than the LAA CL resulting in lower PVfast/LAA ratios compared with the nontermination group (71±10% versus 92±7%; P<0.001). Within the termination group, PVfast/LAA ratios were notably lower if AF terminated after PV isolation or limited adjunctive substrate ablation compared with patients who required moderate or extensive ablation (63±6% versus 75±8%; P<0.001). PVfast/LAA ratio <69% predicted AF termination after PV isolation or limited substrate ablation with 74% positive predictive value and 95% negative predictive value. After a mean follow-up of 29±17 months, freedom from arrhythmia recurrence off-antiarrhythmic drugs was achieved in most patients with PVfast/LAA ratios <69% as opposed to the remaining population (80% versus 43%; P<0.001). The PV to LA CL gradient may identify the subset of patients in whom persistent AF is likely to terminate after PV isolation or limited substrate ablation and better long-term outcomes are achieved. © 2014 American Heart Association, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Atrial Fibrillation - diagnosis
- Atrial Fibrillation - mortality
- Atrial Fibrillation - surgery
- Body Surface Potential Mapping - methods
- Catheter Ablation - methods
- Catheter Ablation - mortality
- Cohort Studies -
- Female -
- Follow-Up Studies -
- Heart Atria - physiopathology
- Hemodynamics - physiology
- Humans -
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Prospective Studies -
- Pulmonary Veins - physiopathology
- Pulmonary Veins - surgery
- Recurrence -
- Risk Assessment -
- Severity of Illness Index -
- Statistics, Nonparametric -
- Survival Analysis -
- Time Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- atrial fibrillation
- cardiac electrophysiology
- pulmonary veins