Medizinische Universität Graz - Research portal
Selected Publication:
Strunk, T; Bubel, S; Mascher, B; Schlenke, P; Kirchner, H; Wandinger, KP.
Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients.
Ann Neurol. 2000; 47(2):269-273
Doi: 10.1002/1531-8249(200002)47:2<269::AID-ANA23>3.0.CO;2-G
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schlenke Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- To determine the frequency of in vivo activated T(H)1 lymphocytes, T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Dipeptidyl Peptidase 4 - metabolism
- Female -
- Humans -
- Interferon-gamma - metabolism
- Ionomycin - pharmacology
- Lymphocyte Count -
- Male -
- Middle Aged -
- Multiple Sclerosis - metabolism Multiple Sclerosis - pathology
- Receptors, CCR5 - metabolism
- Reference Values -
- T-Lymphocytes - drug effects T-Lymphocytes - metabolism T-Lymphocytes - pathology
- Tetradecanoylphorbol Acetate - pharmacology
- Tumor Necrosis Factor-alpha - metabolism