Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Brocks, CP; Pries, R; Frenzel, H; Ernst, M; Schlenke, P; Wollenberg, B.
Functional alteration of myeloid dendritic cells through head and neck cancer.
Anticancer Res. 2007; 27(2): 817-824.
[OPEN ACCESS]
Web of Science
PubMed
- Co-authors Med Uni Graz
- Schlenke Peter
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- Abstract:
- Background: In head and neck squamous cell carcinoma (HNSCC) the secretion of various immunosuppressive mediators contributes to large-scale effects on the immune functions. The influence of HNSCC on various cellular functions of human myeloid dendritic cells (MDC) was analyzed in this work. Materials and Methods: MDCs were isolated from peripheral blood by 'magnetic bead separation'. Cellular functions were analyzed using flow cytometry, migration- and ELISPOT assays as well as cytokine detection assays. Results: HNSCC massively affects MDCs to induce effective T-cell responses. Analysis of MDC migration and cytokine secretion revealed that HNSCC triggers the production of tumor-promoting and immunosuppressive cytokines IL-1 and IL-10 and results in an increased MDC migration activity. CpG-ODN is able to act contradictory to HNSCC. Conclusion: HNSCC is able to modulate various functions of human MDCs. CpG-ODN is suggested as a potential immunostimulatory agent of human MDC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology
- Cell Movement - immunology
- CpG Islands - genetics
- Dendritic Cells - cytology Dendritic Cells - immunology
- Head and Neck Neoplasms - immunology Head and Neck Neoplasms - pathology
- Humans -
- Immunophenotyping -
- Interleukin-6 - biosynthesis
- Interleukins - biosynthesis Interleukins - secretion
- Lymphocyte Activation -
- Middle Aged -
- Monocytes - cytology Monocytes - immunology
- Oligonucleotides - genetics Oligonucleotides - pharmacology
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- dendritic cells
- antigen presentation
- chemotaxis
- tumor immunology