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Hagenström, H; Schlenke, P; Hennig, H; Kirchner, H; Klüter, H.
Quantification of platelet-associated IgG for differential diagnosis of patients with thrombocytopenia.
Thromb Haemost. 2000; 84(5):779-783 Doi: 10.1055/s-0037-1614115
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Co-authors Med Uni Graz: Schlenke Peter
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Abstract:: Immune thrombocytopenia is due to platelet destruction by circulating glycoprotein-specific antibodies and is found in various disorders. Methods for the detection of platelet-associated IgG (PAIgG) are generally sensitive but unspecific, whereas glycoprotein-specific assays are highly specific but less sensitive. Usefully, a sensitive screening method for PAIgG detection would also provide information for differential diagnosis. We developed a quantitative direct Platelet Immunofluorescence Test (PIFT) by flow cytometry and studied 79 thrombocytopenic patients with immune thrombocytopenia and other disorders. The sensitivity of the assay was 94%, its specificity 66% for the detection of a clinically obvious immune thrombocytopenia. PAIgG levels of patients with immune thrombocytopenia differed significantly from those of other patients with low platelet counts (p <0.001). The quantitative PIFT proved to be a sensitive method for PAIgG detection and should therefore be used as a screening method. In addition, it could be helpful for differential diagnosis in marked thrombocytopenia where a MAIPA is not feasible.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Aged, 80 and over -; Autoantibodies - blood Autoantibodies - immunology; Blood Platelets - immunology; Diagnosis, Differential -; Female -; Flow Cytometry -; Humans -; Immunoglobulin G - blood Immunoglobulin G - immunology; Male -; Middle Aged -; Purpura, Thrombocytopenic, Idiopathic - blood Purpura, Thrombocytopenic, Idiopathic - diagnosis Purpura, Thrombocytopenic, Idiopathic - immunology
Find related publications in this database (Keywords): thrombocytopenia; platelet-associated IgG; flow cytometry