Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Frenzel, H; Hoffmann, B; Brocks, C; Schlenke, P; Pries, R; Wollenberg, B.
Toll-like receptor interference in myeloid dendritic cells through head and neck cancer.
Anticancer Res. 2007; 26(6B):4409-4413
[OPEN ACCESS]
Web of Science
PubMed
- Co-authors Med Uni Graz
- Schlenke Peter
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- Abstract:
- Background: In head and neck squamous cell carcinoma (HNSCC) the secretion of various immunosuppressive mediators contributes to large-scale effects on the immune functions. The influence of HNSCC on the Toll-like receptor (TLR) expression profiles of human myeloid dendritic cells (MDCs), which have been identified in human solid tumor tissue of the head and neck, was analysed. Materials and Methods: MDCs were isolated from peripheral blood by 'magnetic bead separation' and subsequently incubated with supernatants of HNSCC permanent cell lines. TLR expression profiles were investigated using flow cytometry and SDS-PAGE. Results: Human MDC from peripheral blood were found to express all human TLRs except TLR4 and TLR9. Incubation of MDC with supernatants of HNSCC resulted in an increased expression of TLR7. Conclusion: The data suggest an interference of TLR7 expression through HNSCC and provide novel evidence of TLR alterations as a potential tumor promoting event in head and neck cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology
- Cell Line, Tumor -
- Dendritic Cells - immunology Dendritic Cells - metabolism
- Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology
- Humans -
- Immunophenotyping -
- Middle Aged -
- Toll-Like Receptors - metabolism
- Find related publications in this database (Keywords)
- HNSCC
- myeloid dendritic cell
- TLR
- immunomodulation