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SHR Neuro Cancer Cardio Lipid Metab Microb
Faust, KB; Finke, D; Klempt-Giessing, K; Randers, K; Zachrau, B; Schlenke, P; Kirchner, H; Goerg, S.
Antigen-induced B cell apoptosis is independent of complement C4.
Clin Exp Immunol. 2007; 150(1): 132-139.
Doi: 10.1111/j.1365-2249.2007.03456.x
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- Co-authors Med Uni Graz
- Schlenke Peter
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- Abstract:
- Deficiencies in early complement components are associated with the development of systemic lupus erythematosus (SLE) and therefore early complement components have been proposed to influence B lymphocyte activation and tolerance induction. A defect in apoptosis is a potential mechanism for breaking of peripheral B cell tolerance, and we hypothesized that the lack of the early complement component C4 could initiate autoimmunity through a defect in peripheral B lymphocyte apoptosis. Previous studies have shown that injection of a high dose of soluble antigen, during an established primary immune response, induces massive apoptotic death in germinal centre B cells. Here, we tested if the antigen-induced apoptosis within germinal centres is influenced by early complement components by comparing complement C4-deficient mice with C57BL/6 wild-type mice. We demonstrate that after the application of a high dose of soluble antigen in wild-type mice, antibody levels declined temporarily but were restored almost completely after a week. However, after antigen-induced apoptosis, B cell memory was severely limited. Interestingly, no difference was observed between wild-type and complement C4-deficient animals in the number of apoptotic cells, restoration of antibody levels and memory response.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigens - immunology
- Apoptosis - immunology
- B-Lymphocytes - immunology
- Complement C4 - deficiency Complement C4 - immunology
- Enzyme-Linked Immunosorbent Assay - methods
- Female -
- Germinal Center - immunology
- Immune Tolerance -
- Immunologic Memory -
- Lupus Erythematosus, Systemic - immunology
- Mice -
- Mice, Inbred C57BL -
- Nitrophenols - immunology
- Phenylacetates -
- Find related publications in this database (Keywords)
- apoptosis
- complement
- memory
- SLE
- tolerance