Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Bux, J; Cassens, U; Dielschneider, T; Duchscherer, M; Edel, E; Eichler, H; Haas, C; Moog, R; Peschke, H; Peters, C; Ryzenkov, I; Schlenke, P; Ullrich, H; Wiesneth, M.
Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study.
Vox Sang. 2003; 85(4):322-325
Doi: 10.1111/j.0042-9007.2003.00373.x
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Schlenke Peter
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- Abstract:
- Data of 507 granulocyte donations from 183 donors were evaluated. No severe granulocyte colony-stimulating factor (G-CSF)-related side-effects were observed. Three donors complained of severe itching following infusion of hydroxyethyl starch (HES). A high proportion (85%) of the donors stated that they would donate granulocytes again. The mean granulocyte yield was 4.3 x 10(10). High-molecular-weight HES resulted in a significantly higher yield compared with low-molecular-weight HES. Mild, but no severe, adverse transfusion reactions were observed in 16% of the recipients. A leucocyte alloimmunization rate of 24% was found. G-CSF stimulation and transfusion of G-CSF-mobilized granulocytes were well tolerated by donors and recipients, respectively.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Arrhythmias, Cardiac - chemically induced
- Blood Donors -
- Cytotoxicity Tests, Immunologic -
- Dizziness - chemically induced
- Drug Eruptions - etiology
- Fatigue - chemically induced
- Female -
- Fever - etiology
- Granulocyte Colony-Stimulating Factor - adverse effects Granulocyte Colony-Stimulating Factor - pharmacology
- Granulocytes - immunology
- Humans -
- Leukapheresis -
- Leukocyte Count -
- Leukocyte Transfusion - adverse effects
- Male -
- Middle Aged -
- Pain - chemically induced
- Recombinant Proteins -
- Find related publications in this database (Keywords)
- granulocyte transfusion
- G-G'SF
- granulocyte apheresis