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SHR Neuro Cancer Cardio Lipid Metab Microb

Fabian, E; Bogner, M; Elmadfa, I.
Age-related modification of antioxidant enzyme activities in relation to cardiovascular risk factors.
Eur J Clin Invest. 2012; 42(1): 42-48. Doi: 10.1111/j.1365-2362.2011.02554.x
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Leading authors Med Uni Graz: Fabian Elisabeth
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Abstract:: Background Since oxidative stress might cause and promote cardiovascular risk factors such as oxidized low-density lipoproteins (oxLDL), apolipoprotein(a) [apo(a)], asymmetric dimethylarginine (ADMA) and fetuin A, we investigated antioxidant enzyme activities in relation to the vascular redox balance and these risk factors in elderly people. Materials and methods For this observational study, a total of 102 subjects were recruited and divided into three groups: A (7074 years/n = 48), B (7579 years/n = 35) and C (=80 years/n = 19). Activities of the erythrocyte antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were determined photometrically oxLDL, apo(a), ADMA and fetuin A by ELISA. Plasma concentrations of the lipid peroxidation products malondialdehyde (MDA) and conjugated dienes (CD) were analysed with HPLC. Results There were no significant age-associated alterations in apo(a) levels, but there was a significant age-related decrease in activities of SOD (A>C, B>C: P < 0.01), CAT (A>C: P < 0.05) and GSH-Px (A>C: P < 0.05), accompanied by a significant increase in oxLDL (AC: P < 0.01; B>C: P < 0.05). Consequently, all groups showed significant negative age-associated correlations between CAT and MDA (A, B, C: P < 0.05), GSH-Px and CD (A, C: P < 0.01; B: P < 0.05), SOD and oxLDL (A, B: P < 0.05; C: P < 0.01), and fetuin A and MDA (A: P < 0.01; B, C: P < 0.05), and a significant positive correlation between oxLDL and ADMA (A, B: P < 0.05; C: P < 0.01). Conclusions This study indicates a significant age-related decrease in antioxidant enzyme activities accompanied by significantly increased systemic oxidative stress, which promotes the cardiovascular risk factors oxLDL, ADMA and fetuin A in elderly people.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged, 80 and over -; Aging - physiology; Apolipoproteins A - blood; Arginine - analogs & derivatives Arginine - blood; Cardiovascular Diseases - enzymology; Catalase - blood; Enzyme-Linked Immunosorbent Assay -; Female -; Fetuins - metabolism; Glutathione Peroxidase - blood; Humans -; Lipid Peroxidation - physiology; Lipoproteins - metabolism; Lipoproteins, LDL - blood; Male -; Oxidation-Reduction -; Oxidative Stress - physiology; Risk Factors -; Statistics as Topic -; Superoxide Dismutase - blood
Find related publications in this database (Keywords): Cardiovascular risk factors; elderly; enzymatic antioxidants; oxidative stress