Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lippe, IT; Sametz, W; Sabin, K; Holzer, P.
Inhibitory role of capsaicin-sensitive afferent neurons and nitric oxide in hemostasis.
Am J Physiol. 1993; 265(6 Pt 2):H1864-H1868
Doi: 10.1152/ajpheart.1993.265.6.H1864
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- Führende Autor*innen der Med Uni Graz
- Lippe Irmgard Theresia
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- Capsaicin-sensitive afferent neurons control blood flow via release of peptide transmitters and formation of nitric oxide (NO). The present study examined whether capsaicin-sensitive afferent neurons and NO interact in the control of hemostasis. Afferent nerve ablation by pretreating rats with a neurotoxic dose of capsaicin (125 mg/kg) led to a 26% reduction of the time of bleeding from punctured small mesenteric arteries in pentobarbital-anesthetized animals. Blockade of NO formation by NG-nitro-L-arginine methyl ester (L-NAME; 10 mg/kg) attenuated the bleeding time in capsaicin-pretreated rats but had no effect in vehicle-pretreated rats. Platelet aggregation induced by ADP was significantly augmented by 12% in capsaicin-pretreated rats. L-NAME did not alter platelet aggregation in vehicle-pretreated rats but enhanced it in capsaicin-pretreated animals. The prothrombin and partial thromboplastin time and the plasma levels of fibrinogen and antithrombin III remained unchanged by capsaicin or L-NAME, whereas the thrombin time was reduced in capsaicin-pretreated rats. These data indicate that capsaicin-sensitive afferent neurons play an inhibitory role in platelet aggregation and hemostasis, a function in which they interact with the NO system.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arginine - analogs & derivatives
- Bleeding Time -
- Blood Coagulation - drug effects
- Calcitonin Gene-Related Peptide - metabolism
- Capsaicin - pharmacology
- Female -
- Hemostasis - drug effects
- NG-Nitroarginine Methyl Ester -
- Neurons, Afferent - drug effects
- Nitric Oxide - antagonists & inhibitors
- Platelet Aggregation - drug effects
- Rats -
- Rats, Sprague-Dawley -
- Stomach - metabolism
- Find related publications in this database (Keywords)
- N(G)-Nitro-L-Arginine Methyl Ester
- Bleeding Time
- Platelet Aggregation
- Blood Coagulation
- Rat