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SHR Neuro Cancer Cardio Lipid Metab Microb

Agic, A; Xu, H; Altgassen, C; Noack, F; Wolfler, MM; Diedrich, K; Friedrich, M; Taylor, RN; Hornung, D.
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Reprod Sci. 2007; 14(5): 486-497. Doi: 10.1177/1933719107304565
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Co-authors Med Uni Graz: Wölfler Monika Martina
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Abstract:: The authors demonstrate expression of the vitamin D receptor (VDR) and its hydroxylases in the endometrium and ovaries of women with and without endometriosis and endometrial or ovarian cancer. Immunohistochemistry showed strong staining of the VDR in endometriosis and endometrial cancer, with the most intense staining in epithelial cells. The VDR mRNA was significantly increased in patients with endometrial and ovarian cancer compared to the control group. There was a significantly higher 1 alpha-hydroxylase expression in the endometrium of patients with endometriosis compared to healthy controls. The observed differences in VDR and 1 alpha -hydroxylase mRNA levels were maintained at the protein level. The authors found no differences in 25-OH vitamin D levels between the serum of patients with endometriosis (25.7 +/- 2.1 ng/mL, n = 46) and healthy controls (22.6 +/- 2.0 ng/mL, n = 33, P = .31). They hypothesize that vitamin D might influence the local activity of immune cells and cytokines thought to play important pathogenic roles in the development and maintenance of endometriosis.
Find related publications in this database (using NLM MeSH Indexing): 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - biosynthesis 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics; Cells, Cultured -; Cholestanetriol 26-Monooxygenase - biosynthesis Cholestanetriol 26-Monooxygenase - genetics; Endometrial Neoplasms - enzymology Endometrial Neoplasms - genetics Endometrial Neoplasms - metabolism; Endometriosis - enzymology Endometriosis - genetics Endometriosis - metabolism; Female -; Gene Expression Regulation, Neoplastic - physiology; Humans -; Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism; Receptors, Calcitriol - biosynthesis Receptors, Calcitriol - genetics; Steroid Hydroxylases - biosynthesis Steroid Hydroxylases - genetics
Find related publications in this database (Keywords): endometriosis; gynecologic cancer; vitamin D; hydroxylases