Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wölfler, MM; Facchinetti, F; Venturini, P; Huber, A; Helmer, H; Husslein, P; Tschugguel, W.
Induction of labor at term using isosorbide mononitrate simultaneously with dinoprostone compared to dinoprostone treatment alone: a randomized, controlled trial.
Am J Obstet Gynecol. 2006; 195(6): 1617-1622.
Doi: 10.1016/j.ajog.2006.03.096
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Wölfler Monika Martina
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- Abstract:
- Objective: We aimed to determine whether isosorbide mononitrate (IMN) given simultaneously with dinoprostone in term pregnancies is superior to dinoprostone alone to promote delivery. Study design: One hundred and twenty nulliparous women at term were randomly assigned to receive per vaginam IMN 40 mg or placebo in addition to 3 mg dinoprostone 2 times daily for up to 2 days. Analysis was by intention to treat. Results: Baseline characteristics of both groups were comparable. The induction to delivery intervals did not differ between the IMN and the placebo group (26.4 +/- 14.4 vs 23.4 +/- 14.8 hours, P = .408). IMN resulted in more headache compared to placebo (32/55 [58.2%] vs 2/55 [3.6%], P < .001). Conclusion: Vaginally administered IMN does not play a role in promoting delivery in term pregnancy if given at the same time as dinoprostone. This might reflect its relaxant effect on the uterine fundus, which may overcome its cervical softening effect. (c) 2006 Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Intravaginal -
- Adult -
- Delivery, Obstetric -
- Dinoprostone - administration & dosage Dinoprostone - adverse effects Dinoprostone - therapeutic use
- Double-Blind Method -
- Drug Therapy, Combination -
- Female -
- Headache - chemically induced
- Humans -
- Isosorbide Dinitrate - administration & dosage Isosorbide Dinitrate - adverse effects Isosorbide Dinitrate - analogs & derivatives Isosorbide Dinitrate - therapeutic use
- Labor, Induced -
- Oxytocics - administration & dosage Oxytocics - adverse effects Oxytocics - therapeutic use
- Pregnancy -
- Time Factors -
- Find related publications in this database (Keywords)
- cervical ripening
- labor induction
- isosorbide mononitrate
- nitric oxide
- term pregnancy