Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Muntean, W; Zenz, W; Finding, K; Zobel, G; Beitzke, A.
Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two-year-old child.
Acta Paediatr. 1994; 83(1):84-87
Doi: 10.1111/j.1651-2227.1994.tb12958.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Muntean Eugen
- Co-Autor*innen der Med Uni Graz
- Beitzke Albrecht
- Zenz Werner
- Zobel Gerfried
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- Abstract:
- A two-year-old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications.
- Find related publications in this database (using NLM MeSH Indexing)
- Anastomosis, Surgical - methods
- Animals - methods
- Blood Coagulation Disorders - etiology
- Cattle - etiology
- Child, Preschool - etiology
- Factor V - antagonists and inhibitors
- Fibrin Tissue Adhesive - adverse effects
- Heart Septal Defects, Ventricular - surgery
- Humans - surgery
- Male - surgery
- Postoperative Complications - surgery
- Pulmonary Artery - surgery
- Subclavian Artery - surgery
- Find related publications in this database (Keywords)
- Factor V Inhibitor
- Fibrin Sealant
- Surgery