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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Xiong, Y; Wong, A; Cavalieri, M; Schmidt, R; Chu, WW; Liu, X; Wong, KS; Mok, V.
Prestroke statins, progression of white matter hyperintensities, and cognitive decline in stroke patients with confluent white matter hyperintensities.
Neurotherapeutics. 2014; 11(3):606-611
Doi: 10.1007/s13311-014-0270-5
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- Co-authors Med Uni Graz
- Cavalieri Margherita
- Schmidt Reinhold
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- Abstract:
- Cerebral white matter hyperintensities (WMH) are a consequence of cerebral small vessel disease. Statins have been shown to reduce recurrent stroke among patients with various stroke subtypes, including lacunar stroke, which also arises from small vessel disease. In this study, we investigated the hypothesis that prestroke statin use would reduce the progression of WMH and/or cognitive decline among stroke patients with confluent WMH. Patients (n = 100) were participants of the VITAmins To Prevent Stroke magnetic resonance imaging substudy. All patients had confluent WMH on magnetic resonance imaging at baseline. Eighty-one patients completed the 2-year follow-up. We assessed general cognition and executive function using the mini-mental state examination and Mattis dementia rating scale-initiation/perseveration subscale, respectively. We compared the change in volume of WMH and cognition between prestroke statin use and prestroke nonstatin use groups. We also evaluated the effects of prestroke statin use on incident lacunes and microbleeds. The prestroke statin use group (n = 51) had less WMH volume progression (1.54 ± 4.52 cm(3) vs 5.01 ± 6.00 cm(3), p = 0.02) compared with the prestroke nonstatin use group (n = 30). Multivariate linear regression modeling identified prestroke statin use as an independent predictor of WMH progression (β = -0.31, p = 0.008). Prestroke statin use was also associated with less decline (Mattis dementia rating scale-initiation/perseveration subscale; β = 0.47, p = 0.001). No association was observed with changes in mini-mental state examination scores. There were no between group differences on incident lacunes or incident microbleeds. Prestroke statin use may reduce WMH progression and decline in executive function in stroke patients with confluent WMH.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Cerebral Cortex - blood supply
- Cerebral Cortex - pathology
- Cerebral Small Vessel Diseases - complications
- Cerebral Small Vessel Diseases - drug therapy
- Cerebral Small Vessel Diseases - pathology
- Cognition Disorders - drug therapy
- Cognition Disorders - etiology
- Disease Progression -
- Female -
- Folic Acid - therapeutic use
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Stroke - complications
- Vitamin B 12 - therapeutic use
- Vitamin B 6 - therapeutic use
- White Matter - pathology
- Find related publications in this database (Keywords)
- Statins
- White matter hyperintensities
- Stroke
- Cognitive decline