Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dalpiaz, O; Pichler, M; Mannweiler, S; Martín Hernández, JM; Stojakovic, T; Pummer, K; Zigeuner, R; Hutterer, GC.
Validation of the pretreatment derived neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma.
Br J Cancer. 2014; 110(10):2531-2536
Doi: 10.1038/bjc.2014.180
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- Führende Autor*innen der Med Uni Graz
- Dalpiaz Orietta
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Hutterer Georg
- Mannweiler Sebastian
- Martin Hernandez Jessica Maria
- Pummer Karl
- Stojakovic Tatjana
- Zigeuner Richard
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- Abstract:
- The value of a combined index of neutrophil and white cell counts, named derived neutrophil-lymphocyte ratio (dNLR), has recently been proposed as a prognosticator of survival in various cancer types. We investigated the prognostic role of the dNLR in a large European cohort of patients with upper tract urothelial carcinoma (UTUC). Data from 171 non-metastatic UTUC patients, operated between 1990 and 2012 at a single tertiary academic centre, were evaluated retrospectively. Cancer-specific- (CSS) as well as overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the dNLR, multivariate proportional Cox-regression models were applied. Additionally, the influence of the dNLR on the predictive accuracy of the multivariate model was further determined by Harrell's concordance index (c-index). The median follow-up period was 31 months. An increased dNLR was statistically significantly associated with shorter CSS (log-rank P=0.004), as well as with shorter OS (log-rank P=0.002). Multivariate analysis identified dNLR as an independent predictor for CSS (hazard ratio, HR=1.16, 95% confidence interval, CI=1.01-1.35, P=0.045), as well as for OS (HR=1.21, 95% CI=1.09-1.34, P<0.001). The estimated c-index of the multivariate model for OS was 0.68 without dNLR and 0.73 when dNLR was added. Patients with a high pretreatment dNLR could be predicted to show subsequently higher cancer-specific- as well as overall mortality after surgery for UTUC compared with those with a low pretreatment dNLR. Thus, this combined index should be considered as a potential prognostic biomarker in future.
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- Aged -
- Aged - epidemiology
- Carcinoma, Transitional Cell - blood
- Carcinoma, Transitional Cell - mortality
- Confounding Factors (Epidemiology) -
- Female -
- Follow-Up Studies -
- Humans -
- Kaplan-Meier Estimate -
- Kidney Neoplasms - blood
- Kidney Neoplasms - mortality
- Kidney Neoplasms - surgery
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- Middle Aged -
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- Neutrophils -
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- Find related publications in this database (Keywords)
- derived neutrophil-lymphocyte ratio
- prognosis
- survival
- upper tract urothelial carcinoma
- validation study