Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Dapunt, OE; Midulla, PS; Sadeghi, AM; Mezrow, CK; Wolfe, D; Gandsas, A; Zappulla, RA; Bodian, CA; Ergin, MA; Griepp, RB.
Pathogenesis of spinal cord injury during simulated aneurysm repair in a chronic animal model.
Ann Thorac Surg. 1994; 58(3):689-696
Doi: 10.1016/0003-4975(94)90729-3
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Dapunt Otto Eugen
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The pathogenesis of paraplegia after repair of thoracic aortic aneurysms is controversial. Using direct spinal cord evoked potential monitoring, critical intercostal arteries (CICA) were identified to evaluate the impact of backbleeding and ligation versus that of preservation during simulated aneurysm repair. Thirty pigs (40 kg) were randomly assigned to one of five groups. In groups 1 through 4, a thoracic segment containing CICA was cross-clamped for 60 minutes and distal aortic perfusion was provided by a centrifugal pump. In groups 1 and 2, the thoracic segment was vented, maintaining segment pressure at 0 mm Hg; CICA were ligated in group 1 and preserved in group 2. Thoracic segment was perfused at 70 mm Hg in groups 3 and 4; CICA were ligated in group 3 and preserved in group 4. Critical intercostal artery ligations were performed at the end of the cross-clamp period. In group 5 simple cross-clamping at the left subclavian artery was performed as a control. The combination of venting and ligation of CICA correlated with impaired neurologic outcome according to Tarlov's score (median, 1.5 in group 1 versus 3 in group 2; p = 0.015), indicated by a significant difference in median values of direct spinal cord evoked potential amplitude (expressed as a fraction of baseline values) at 120 minutes after cross-clamping (0.76 in group 1 versus 0.98 in group 2; p = 0.0082).(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aortic Aneurysm, Thoracic - surgery
- Arteries - surgery
- Chronic Disease -
- Constriction -
- Evoked Potentials, Somatosensory -
- Female -
- Ligation -
- Models, Biological -
- Paraplegia - etiology
- Paraplegia - physiopathology
- Postoperative Complications - etiology
- Postoperative Complications - physiopathology
- Random Allocation -
- Spinal Cord - blood supply
- Spinal Cord - pathology
- Spinal Cord Injuries - etiology
- Spinal Cord Injuries - physiopathology
- Swine -