Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Bonatti, J; Dichtl, W; Dworzak, EA; Antretter, H; Unger, F; Puschendorf, B; Dapunt, OE.
Atrial natriuretic peptide-induced release of cyclic guanosine monophosphate by coronary bypass grafts.
Ann Thorac Surg. 1998; 65(6):1621-1624
Doi: 10.1016/S0003-4975(98)00267-7
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Dapunt Otto Eugen
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- Abstract:
- Superior long-term patency rates of the internal mammary artery (IMA) versus saphenous vein (SV) after coronary artery bypass grafting are well documented. Higher production rates of vasodilating and platelet-inhibiting mediators (prostacyclin and nitric oxide) by the IMA seem to have a major impact on its long-term durability and resistance to coronary artery graft disease. For the right gastroepiploic artery (RGEA) marked release of protective mediators is reported as well. The vasodilating effect of cyclic guanosine monophosphate (cGMP) released after stimulation by atrial natriuretic peptide might serve as another graft protective system. The aim of the present study was to determine cGMP release by IMA, RGEA, and SV after atrial natriuretic peptide challenge. Samples of human IMA (n = 19), RGEA (n = 7), and SV (n = 18) discarded during coronary artery bypass grafting were stimulated with 10(-6) mol/L atrial natriuretic peptide after a resting phase in nutrient medium. Release of cGMP was determined by 125-iodide radioimmunoassay. Basal cGMP production rates of the IMA (759.9 +/- 277.0 fmol/cm2) and RGEA (739.9 +/- 186.0 fmol/cm2) were higher than production rates of SV (281.2 +/- 64.0 fmol/cm2). Application of atrial natriuretic peptide led to a statistically significant increase of cGMP release in IMA grafts (1,939.3 +/- 778.0 fmol/cm2), whereas RGEA (618.4 +/- 141.3 fmol/cm2) and SV (221.7 +/- 64.5 fmol/cm2) remained at basal levels (p < 0.05). From these data we conclude that the IMA in comparison with the RGEA and SV produces more extracellular cGMP when stimulated by atrial natriuretic peptide. This effect might support the cGMP-mediated protective properties of nitric oxide and could underline the extraordinary suitability of the IMA as a bypass conduit.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Muscles - blood supply
- Arteries - metabolism
- Atrial Natriuretic Factor - administration & dosage
- Atrial Natriuretic Factor - pharmacology
- Coronary Artery Bypass - methods
- Coronary Disease - physiopathology
- Culture Techniques -
- Cyclic GMP - metabolism
- Epoprostenol - metabolism
- Humans -
- Internal Mammary-Coronary Artery Anastomosis -
- Iodine Radioisotopes -
- Mammary Arteries - enzymology
- Nitric Oxide - metabolism
- Omentum - blood supply
- Platelet Aggregation Inhibitors - metabolism
- Radiopharmaceuticals -
- Saphenous Vein - enzymology
- Vascular Patency -
- Vasodilator Agents - metabolism