Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grübler, MR; Kienreich, K; Gaksch, M; Verheyen, N; Fahrleitner-Pammer, A; Schmid, J; Grogorenz, J; Ablasser, K; Pieske, B; Tomaschitz, A; Pilz, S.
Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertensive patients: the Styrian Hypertension Study.
J Clin Hypertens (Greenwich). 2014; 16(4):289-94
Doi: 10.1111/jch.12274
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- Führende Autor*innen der Med Uni Graz
- Grübler Martin
- Co-Autor*innen der Med Uni Graz
- Ablasser Klemens
- Fahrleitner-Pammer Astrid
- Keppel Martin Helmut
- Kienreich Katharina
- Pieske Burkert Mathias
- Pilz Stefan
- Schmid Johannes
- Tomaschitz Andreas
- Verheyen Nicolas Dominik
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- Abstract:
- High aldosterone levels are considered to play a key role in arterial hypertension. Data on the relationship between the aldosterone to active renin ratio (AARR), a quantity of aldosterone excess, and ambulatory blood pressure (BP) monitoring (ABPM) during the night are, however, sparse. Hypertensive patients were recruited from local outpatient clinics who underwent 24-hour urine collection and in parallel ABPM. Plasma aldosterone and renin concentrations were measured by radioimmunoassay. A total of 211 patients (age, 60.2±10.2 years; 51.9% female) with a mean systolic/diastolic ABPM value of 128.7±12.8/77.1±9.2 mm Hg were evaluated. In backwards linear regression analyses adjusted for age, sex, body mass index, smoking, glomerular filtration rate, hemoglobin A1c , N-terminal prohormone of brain natriuretic peptide, urinary sodium/potassium ratio, and ongoing antihypertensive medication, AARR was significantly associated with nocturnal systolic (ß-coefficient: 0.177; P=.017) and diastolic BP (ß-coefficient: 0.162; P=.027). In patients with arterial hypertension, a significant association between AARR and nighttime BP even after adjustment for a broad panel of confounders was found.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Aldosterone - blood
- Antihypertensive Agents - therapeutic use
- Austria - administration & dosage
- Blood Pressure - physiology
- Blood Pressure Monitoring, Ambulatory - administration & dosage
- Body Mass Index - administration & dosage
- Circadian Rhythm - physiology
- Cohort Studies - administration & dosage
- Cross-Sectional Studies - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Hypertension - blood, drug therapy, physiopathology
- Linear Models - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Obesity - blood, physiopathology
- Radioimmunoassay - administration & dosage
- Renin - blood