Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Homayoon, N; Schwingenschuh, P; Hofer, E; Katschnig-Winter, P; Schmidt, R.
Anticardiolipin antibodies are associated with cognitive dysfunction in stroke-free individuals.
Eur J Neurol. 2014; 21(3): e21- e22
Doi: 10.1111/ene.12316
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Homayoon-Perchtold Nina
- Schmidt Reinhold
- Co-authors Med Uni Graz
- Hofer Edith
- Katschnig-Winter Petra
- Schwingenschuh Petra
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- Abstract:
- The presence of anticardiolipin antibodies (aCLs) has been associated with vascular occlusive events. The role of aCLs as a risk factor for stroke has been a matter of debate, and scarce information exists on the relationship between aCLs and other cerebral disorders. Reports exist for seizures, chorea and subtle cognitive dysfunction. The association between aCLs and cognition was further explored and the relationship between aCL titres and brain magnetic resonance imaging (MRI) findings was evaluated in a large cohort of community-dwelling individuals. The study cohort was drawn from the Austrian Stroke Prevention Study. A total of 1895 subjects had a complete risk factor assessment and measurement of aCL titres in serum. Participants were classified as aCL positive if either the immunoglobulin G (IgG) or IgM aCL titres were elevated (IgG > 21 U/ml, IgM > 12 U/ml). All subjects were also categorized based on the quartile distribution of IgG and IgM isotype titres. All underwent cognitive testing by the Mini Mental State Examination (MMSE) and a random sample of 947 participants also underwent brain MRI. aCL positive participants performed worse on the MMSE. IgG but not IgM isotype titres related to worse performance on the MMSE. No significant association existed with vascular brain abnormalities including lacunes, cortical infarcts and white matter lesions. These data support the view that in normal elderly persons increasing IgG aCL titres relate to global cognitive dysfunction. It is unlikely that structural brain lesions are responsible for this finding. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged -
- Cardiolipins - immunology
- Cognition Disorders - blood Cognition Disorders - etiology
- Cohort Studies -
- Female -
- Humans -
- Immunoglobulins - blood
- Linear Models -
- Magnetic Resonance Imaging -
- Male -
- Mental Status Schedule -
- Middle Aged -
- Risk Factors -
- Statistics, Nonparametric -
- Stroke - complications
- Find related publications in this database (Keywords)
- anticardiolipin antibodies
- brain magnetic resonance imaging
- cognition
- vascular brain lesions