Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Heinemann, A; Sattler, V; Jocic, M; Holzer, P.
Inhibition of acid-induced hyperaemia in the rat stomach by endogenous NK2 receptor ligands.
NEUROSCI LETT 1997 237: 133-135.
Doi: 10.1016%2FS0304-3940%2897%2900831-8
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- Führende Autor*innen der Med Uni Graz
- Heinemann Akos
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- Since exogenously applied tachykinins (substance P and neurokinin A) prevent the neurogenic hyperaemia which is elicited by acid back-diffusion in the rat stomach, we investigated whether endogenous tachykinins would act in a similar manner. Acid back-diffusion, induced by perfusing the stomach with 15% ethanol in the presence of 0.05 M HCI, increased gastric mucosal blood flow (GMBF) by 60-100% as determined by hydrogen clearance in urethane-anaesthetized rats. This response remained unchanged after pretreatment with the tachykinin NK1 receptor antagonist SR 140,333 (300 nmol/kg) but tended to be enhanced by the NK2 receptor antagonist MEN 10,627 (200 nmol/kg). When given during ongoing acid back-diffusion, MEN 10,627 significantly enhanced the acid-evoked vasodilatation as compared with vehicle or SR 140,333. We conclude that endogenously released tachykinins, acting via NK2 receptors, limit the gastric hyperaemic response to acid.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Female - drug effects
- Gastric Acid - physiology
- Heart Rate - drug effects
- Hyperemia - chemically induced
- Ligands - chemically induced
- Peptides, Cyclic - pharmacology
- Piperidines - pharmacology
- Quinuclidines - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Receptors, Neurokinin-1 - metabolism
- Receptors, Neurokinin-2 - metabolism
- Regional Blood Flow - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Stomach - blood supply
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Acid Back-Diffusion
- Gastric Mucosal Blood Flow
- Tachykinin Receptors