Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grammer, TB; Kleber, ME; Silbernagel, G; Pilz, S; Scharnagl, H; Lerchbaum, E; Tomaschitz, A; Koenig, W; März, W.
Copper, ceruloplasmin, and long-term cardiovascular and total mortality (the Ludwigshafen Risk and Cardiovascular Health Study).
Free Radic Res. 2014; 48(6):706-715
Doi: 10.3109/10715762.2014.901510
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- März Winfried
- Pilz Stefan
- Scharnagl Hubert
- Silbernagel Günther
- Tomaschitz Andreas
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- Abstract:
- Copper and its main transport protein ceruloplasmin have been suggested to promote the development of atherosclerosis. Most of the data come from experimental and animal model studies. Copper and mortality have not been simultaneously evaluated in patients undergoing coronary angiography. We examined whether serum copper and ceruloplasmin concentrations are associated with angiographic coronary artery disease (CAD) and mortality from all causes and cardiovascular causes in 3253 participants of the Ludwigshafen Risk and Cardiovascular Health Study. Age and sex-adjusted hazard ratios (HR) for death from any cause were 2.23 (95% CI, 1.85-2.68) for copper and 2.63 (95% CI, 2.17-3.20) for ceruloplasmin when we compared the highest with the lowest quartiles. Corresponding hazard ratios (HR) for death from cardiovascular causes were 2.58 (95% CI, 2.05-3.25) and 3.02 (95% CI, 2.36-3.86), respectively. Further adjustments for various risk factors and clinical variables considerably attenuated these associations, which, however, were still statistically significant and the results remained consistent across subgroups. The elevated concentrations of both copper and ceruloplasmin are independently associated with increased risk of mortality from all causes and from cardiovascular causes.
- Find related publications in this database (using NLM MeSH Indexing)
- Ceruloplasmin - analysis
- Copper - blood
- Coronary Angiography -
- Coronary Artery Disease - blood Coronary Artery Disease - mortality Coronary Artery Disease - pathology
- Female -
- Heart Failure - blood Heart Failure - mortality Heart Failure - pathology
- Humans -
- Inflammation - blood Inflammation - immunology
- Male -
- Middle Aged -
- Oxidative Stress -
- Risk Factors -
- Find related publications in this database (Keywords)
- oxidative stress
- coronary artery disease
- mortality
- copper
- ceruloplasmin
- inflammation