Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Navarro, FA; So, PT; Nirmalan, R; Kropf, N; Sakaguchi, F; Park, CS; Lee, HB; Orgill, DP.
Two-photon confocal microscopy: a nondestructive method for studying wound healing.
Plast Reconstr Surg. 2004; 114(1): 121-128.
Doi: 10.1097/01.PRS.0000128374.20913.4B
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Fuchsjäger Nina
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- Abstract:
- Two-photon confocal microscopy is a new technology useful in nondestructive analysis of tissue. The pattern generated from laser-excited autofluorescence and second harmonic signals can be analyzed to construct a three-dimensional, microanatomical, structural image. The healing of full-thickness guinea pig skin wounds was studied over a period of 28 days using two-photon confocal microscopy. Three-dimensional data were rendered from two-dimensional images and compared with conventional, en face, histologic sections. Two-photon confocal microscopy images show resolution of muscle, fascia fibers, collagen fibers, inflammatory cells, blood vessels, and hair. Although these images do not currently have the resolution of standard histology, the ability to noninvasively acquire three-dimensional images of skin promises to be an important tool in wound-healing studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Female -
- Guinea Pigs -
- Imaging, Three-Dimensional - methods
- Microscopy, Confocal - instrumentation Microscopy, Confocal - methods
- Skin - injuries Skin - pathology
- Wound Healing - physiology