Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Schwetz, V; Giuliani, A; Obermayer-Pietsch, B.
Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women.
Eur J Endocrinol. 2014; 170(5):727-739
Doi: 10.1530/EJE-13-1035
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- Giuliani Albrecht
- Obermayer-Pietsch Barbara
- Theiler-Schwetz Verena
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- Abstract:
- There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS. Cross-sectional study. We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women. A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent association of T2DM FHx with central fat accumulation, obesity, prediabetes, metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure (P<0.05 for all). PCOS FHx was independently associated with prediabetes (P<0.05). We observed an independent association of PCOS FHx with clinical and biochemical hyperandrogenism (P<0.05 for all), whereas there was no independent association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of both T2DM and PCOS had an adverse metabolic and endocrine profile including a linear increase in risk of obesity, central fat accumulation, MS, prediabetes and low HDL (P<0.05 for all). Our findings suggest that the assessment of FHx might allow risk stratification of PCOS women, which is important considering the high prevalence of PCOS.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Fat - pathology
- Adiposity -
- Adult -
- Adult - epidemiology
- Body Mass Index -
- Cohort Studies -
- Cross-Sectional Studies -
- Diabetes Mellitus, Type 2 - epidemiology
- Dyslipidemias - epidemiology
- Family Health -
- Female -
- Humans -
- Hyperandrogenism - epidemiology
- Hypertension - epidemiology
- Insulin Resistance -
- Metabolic Syndrome X - epidemiology
- Obesity - epidemiology
- Polycystic Ovary Syndrome - blood
- Prediabetic State - epidemiology
- Risk Factors -