Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schweighofer, N; Lerchbaum, E; Trummer, O; Schwetz, V; Pieber, T; Obermayer-Pietsch, B.
Metformin resistance alleles in polycystic ovary syndrome: pattern and association with glucose metabolism.
Pharmacogenomics. 2014; 15(3):305-317
Doi: 10.2217/pgs.13.223
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Schweighofer Natascha
- Co-authors Med Uni Graz
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Theiler-Schwetz Verena
- Trummer Olivia
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- Abstract:
- Insulin-sensitizer treatment with metformin is common in polycystic ovary syndrome (PCOS). OCT alleles were investigated in PCOS patients to identify genetic 'bad responders' and 'nonresponders' to metformin including their possible effects on glucose metabolism without treatment. We genotyped eight SNPs in OCT1, OCT2 and ATM genes in 676 women with PCOS and 90 control women, we also measured oral glucose tolerance tests prior to treatment. Nonfunctional alleles were present in 29.8% and low-functional alleles in 57.9% of our PCOS cohort. OCT variants were significantly associated with elevated baseline and glucose-induced C-peptide levels in PCOS. Metformin bad responders or nonresponders based on OCT genotypes might be relevant in clinical practice - their modulation of metformin pharmacokinetics and pharmacodynamics and metformin-independent glucose effects remain to be elucidated.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Ataxia Telangiectasia Mutated Proteins - genetics
- C-Peptide - metabolism
- Drug Resistance - genetics
- Female -
- Genetic Association Studies -
- Glucose - metabolism
- Glucose Tolerance Test -
- Humans -
- Insulin Resistance - genetics
- Metformin - administration & dosage
- Organic Cation Transport Proteins - genetics
- Organic Cation Transporter 1 - genetics
- Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - pathology
- Polymorphism, Single Nucleotide -
- Find related publications in this database (Keywords)
- ATM
- C-peptide
- metformin resistance
- organic cation transporters
- polycystic ovary syndrome
- SNPs